Abstract
Raman spectra of Cinnarizine in the 35–3400 cm-1 region were studied at high pressures up to 15.3 GPa, using a Diamond Anvil Cell. Broadening of bands is observed starting from ∼0.9 up to ∼11–12 GPa pressures as evidenced by the changes in the Raman spectra of some modes. Plots of frequency vs pressure of bands, show increase of frequency with pressure for most of the bands and the slopes, dω/dP, of some bands show clear changes around ∼2.7, ∼5, ∼7.5 ∼9 and ∼11–12 GPa indicating phase transformation caused by changes in structure and chemical bonds at these pressures. The present article describes high pressure effects on cinnarizine studied by Raman Spectroscopy and is supported by density function theoretical calculations.
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