Abstract
Optical activity associated with the vibrations of chiral molecules can be measured by means of a small difference in the intensity of Raman scattering in right and left circularly polarized incident light. This technique enables complete vibrational optical activity spectra from about 50 to 4000 cm-1 to be measured routinely, although the largest effects occur at low frequency. The basic theory of Raman optical activity is developed, together with a ‘bond-polarizability’ theory which gives the sign and magnitude of the effects generated by idealized normal modes of model chiral structures. The experimental method is described briefly, and some typical Raman optical activity spectra presented. Correlations pointed out include features in methyl and trifluoromethyl asymmetric deformations, carbon-methyl deformations, methyl torsions, carbonyl deformations, methyl rocking in single methyl groups and in isopropyl group, skeletal vibrations and carbon-hydrogen and carbon-deuterium deformations.
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