Abstract
Raman opportunities in the field of pathological calcifications
Highlights
First described in 1928 by Raman and Krishnan [1] from which it gets its name and predicted theoretically by Smekal in 1923 [2], Raman spectroscopy is an optical spectroscopy which allows the vibrational signatures of probed compounds to be extracted from the scattered light upon illumination of a sample with a monochromatic excitation source [3,4]
Raman spectra represent on the x-axis either the wavelength (λ: nm) or the energy (ν: wavenumber in inverse centimeter cm−1) associated with the optical transitions and on the y-axis their probability of occurrence
One main strength of Raman spectroscopy lies in the fact that the chemical signature is contained in the scattered light collected upon irradiation with a monochromatic laser source
Summary
First described in 1928 by Raman and Krishnan [1] from which it gets its name and predicted theoretically by Smekal in 1923 [2], Raman spectroscopy is an. It has been applied to complex biological samples, such as fluids [9,10], cells [11,12], minerals as physiological [13,14,15] and pathological calcifications [16,17,18] and tissues [19] Such versatility explains the numerous applications of Raman spectroscopy in different specialties of medicine [20,21,22], among which are nephrology [23,24,25,26,27,28,29,30], rheumatology [31,32,33], hematology [34,35,36], gastroenterology [37,38] or endocrinology [39,40]. A literature review focusing on pathological calcifications and featuring the most recent works will be presented
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