Abstract
Background: Retinaldehyde and glycolic acid RALGA (Diacnéal<sup>®</sup>) are both effective in the topical treatment of acne. A decrease in the postinflammatory pigmentation has been observed after application of Diacnéal during 3 months. Aim: To verify the effect of this association on pigmentation using an original model of surviving human skin. Methods: Human skin explants were maintained alive in organ culture for 14 days. Diacnéal<sup>®</sup> was applied every day. Pigmentation of skin, depending on the transfer of melanosomes from melanocytes to keratinocytes, was visualized histologically by Fontana-Masson staining. The number of melanocytes was determined after the DOPA reaction. Results: A decrease in melanin content was shown after application of Diacnéal. The number of melanocytes was not modified. Conclusion: These results suggest that RALGA (Diacnéal<sup>®</sup>) may be of interest to prevent the postinflammatory pigmentation of acne.
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