Abstract
The raised-volume rapid thoracoabdominal compression (RVRTC) manoeuvre has been applied to obtain full forced expiratory flow-volume curves in infants. No reference data are available for Asian populations. This study was conducted to establish predictive reference equations for Taiwanese infants. Full-term infants without any chronic disease or major anomaly were enrolled from this cohort study. Full forced expiratory flow-volume curves were acquired using RVRTC manoeuvres through Jaeger’s system. Tidal breath analysis, passive respiratory mechanics, and tidal forced expiratory flow-volume curves were performed and collected at the same measurement. Multiple linear analyses were used to model the variables. We performed 117 tests of RVRTC flow-volume curves in 97 infants. The results revealed that all parameters, except for FEV0.5 /FVC, correlated highly and positively with body length. These parameters correlated significantly with other parameters of passive respiratory mechanics and tidal forced expiratory flow-volume curves. This is the first study to establish equipment-specific reference data of full forced expiration using RVRTC manoeuvres in Asian infants. The results revealed that parameters of RVRTC manoeuvres are moderately related to other parameters of infant lung function. These race-specific reference data can be used to more precisely and efficiently diagnose respiratory diseases in infants of Chinese ethnicity.
Highlights
The raised-volume RTC (RVRTC) technique, initiated near total lung capacity, has been utilised to obtain a full forced expiratory flow-volume curve
Compared with the transformed Z-scores of ILF parameters, except for those measured while performing partial forced expiration (e.g., VmaxFRC), the raised-volume rapid thoracoabdominal compression (RVRTC) flow-volume curve lowly correlated with the parameters obtained from other ILF manoeuvres
RVRTC technique is a revision of tidal RTC manoeuvres that passively inflated infant’s lung toward total lung capacity before applying RTC
Summary
The raised-volume RTC (RVRTC) technique, initiated near total lung capacity, has been utilised to obtain a full forced expiratory flow-volume curve. Except the regression curve of FEV0.5/FVC, all these parameters exhibited a positive linear correlation with body length. To investigate the correlation of the various parameters of the RVRTC flow-volume curve with
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