Raised Red Cell Distribution Width as a Prognostic Tool for Acute Aluminium Phosphide Poisoning (AALPP) Patients

Abstract

Objectives & Aims: Identify the acute aluminium phosphide poisoning. Identify the acute aluminium phosphide poisoning induced changes in hematological parameters .Raised red cell distribution used as a prognostic tool for acute aluminium phosphide poisoning . The changed hematological parameter used as a survival index of acute aluminium phosphide poisoning patients. Material & Methods: Blood was collected in a sterile EDTA containing tube and processed following our established ISO certified hospital laboratory protocol .A complete blood counting including HB%,PCV, Red cell indices ,platelet count and total white cell count and differential was done by Automated blood cell counter with peripheral blood smear examination and further confirmed by manual oil immersion smear study method. Peripheral smears study was done with field A and B stain and leishman stain. Conclusion: Aluminium phosphide poisoning caused changes in size of peripheral red blood cell due to lipid per oxidation and oxidative stress of cell membrane. These oxidative stress and lipid per oxidations lead to damage the cell membrane of RBC. These damage directly related with severity of exposer of the Aluminium phosphide. This type of damages decided the outcome survival of patients. So variable size of RBC occurs in peripheral blood used as a prognostic tool for severity of toxicity, monitoring of patients ,follow-up and outcome survival in the form of RDW .The RDW is a hematological parameter is easily generated by all type of hematological cell counters used as a good prognostic tool for acute aluminium phosphide poisoning Keyword: aluminium phosphide poisoning, Red cell distribution width. Material & Methods Study area and designThis present study was conducted at the Department of Pathology curewell hospital Pvt Ltd Indore MP. The study was designed as a observational hospital based study over a period of time from 2011 to 2016 years. Ethical ConsiderationBlood was collected in a sterile EDTA containing tube and processed following our established laboratory protocol then generate the report of each patient. Take informed consent was obtained from all study participant for use of your blood sample for medical research after doing physician request investigating and generate the report. Patient’s Selection CriteriaThe study target all the acute aluminium phosphide poisoning toxicity patients on the basis of clinical signs, www.jmscr.igmpublication.org Impact Factor 5.244 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: http://dx.doi.org/10.18535/jmscr/v4i10.28