Abstract
Dietary sodium restriction in five normal subjects led to highly significant increases of plasma-angiotensin-II after 2 days. These changes became even more pronounced after 4 and 5 days. There were parallel increases in plasma-aldosterone. Both angiotensin II and aldosterone returned to control values after sodium repletion. There was a significant positive correlation between concurrent measurements of plasma-aldosterone and plasma-angiotensin-II, and a significant inverse correlation between concurrent plasma-aldosterone and serum-sodium. These findings differ from two other studies of similar design, where dietary sodium restriction produced no detectable change in angiotensin II, despite in one instance a pronounced increase in aldosterone similar to that observed in this study.
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