Abstract
Loss of appetite is a common symptom of acute mountain sickness (AMS). 1 Sampson JB Cymerman A Burse RL Maher JT Rock PB Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med. 1983; 54: 1063-1073 PubMed Google Scholar Weight loss, induced by increased energy expenditure and reduced food intake, occurs during prolonged exposure to altitudes above 5000 m. Loss of fat accounts for up to 74% of this weight loss. 2 Westerterp KR Kayser B Wouters L Le-Trong JL Richalet JP Energy balance at high altitude of 6542 m. J Appl Physiol. 1994; 77: 862-866 PubMed Google Scholar Because leptin is a key mediator in the neuroendocrine regulation of energy homoeostasis and appetite, 3 Auwerx J Staels B Leptin. Lancet. 1998; 351: 737-742 Summary Full Text Full Text PDF PubMed Scopus (521) Google Scholar we investigated the effect of hypobaric hypoxia at high altitude on serum leptin concentrations, using a sensitive and specific method of measurement. 4 Tschöp M Wu Z Bidlingmaier M Heiman ML Strasburger CJ Generation of monoclonal antibodies and establishment of a sensitive sandwich immunoassay for the measurement of human serum leptin. Exp Clin Endocrinol Diabetes. 1998; 106: 40 Google Scholar
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