Abstract
Fibrin/fibrinogen degradation products (F.D.P.) have been measured in amniotic fluid from normal pregnancies and in pregnancies complicated by fetal anencephaly and open spina bifida. Statistically significant increases of amniotic-fluid F.D.P. levels were found in anencephalic pregnancies in the second trimester and third trimester, and also in spina-bifida pregnancies in the second trimester, when compared with levels in normal pregnancies. Amniotic-fluid F.D.P. may be of value as a protein marker in certain fetal neural-tube anomalies.
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