Abstract
Evidence for functional significance of lipid microdomains steadily accumulates. In a recent instalment, Stulnig et al.1 Stulnig T.M. Berger M. Sigmund T. Raederstorff D. Stockinger H. Waldhäusl W. Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains. J. Cell Biol. 1998; 143: 637-644 Crossref PubMed Scopus (234) Google Scholar find that signal transduction across T-cell plasma membranes requires intact detergent-resistant membrane domains (DRMs). Full activation or anergy in T cells occurs when both the T-cell receptor–CD3 complex and a group of glycosylphosphatidylinositol (GPI)-anchored proteins are stimulated at the cell surface. DRMs, it now appears, might facilitate passage of signals from the surface-tethered costimulatory molecules to the cytoplasm.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
