Abstract
A series of well-defined thermoresponsive ABA-type triblock copolymers poly(N-isopropylacrylamide)-b-poly(n-octadecylacrylate)-b-poly(N-isopropylacrylamide) (PNIPAAm-b-PODA-b-PNIPAAm) consisting of two blocks of PNIPAAm and one block of PODA in different ratio are prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization. The structures of the copolymers are characterized by 1HNMR. All block copolymers show lower critical micelle concentration (CMC) (<10 mg/L) in water, indicating the strong tendency of the triblock copolymers to self-assemble into highly stable micelles. It is interesting that the resulting micelles demonstrate double lower critical solution temperature (LCST) behavior. Dynamic light-scattering (DLS) experiments show that the micelles are well dispersed at nanoscale and have a narrow size distribution. Moreover, the drug-loading behavior of micelles is further investigated. The high drug encapsulation efficiency indicates the potential of micelles formed from PNIPAAm-b-PODA-b-PNIPAAm as drug carriers.
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