Abstract
Famotidine (FMT) is known as a histamine blocker (H2) that inhibits stomach acid production and it is commonly used in the treatment of peptic ulcer disease and gastric-esophageal reflux disease. It has a short half life (2.5-3.5 hours), low bioavailability (40-45%). It has excellent solubility in acidic pH just reverse in alkaline pH. Therefore an attempt has been made to develop raft buoyant gastro-retentive sustains release delivery system with in situ gelling property which is based on thixotropy behavior. Twelve formulations (Excluding two controlled formulations i.e. F and F*) were designed to contain 40 mg of FMT using Chitosan; CH (cationic polymer), Sodium Alginate; SA (anionic polymer), Gelucire 43/01; G 43/01 (lipid phase) as retardant and adhesive polymers. Emulgel was prepared and evaluated for their physicochemical properties like buoyancy and lag time, cumulative % drug release, drug release kinetics and drug excipient interaction studies by thermal studies and functional group characterization. All formulations showed that with the increase in concentration of the polymer, the gel strength increased, but the % drug release decreased F8>F12>F11>F6>F5>F10>F7>F9>F3>F4>F1>F2>F*>F. Formulations F9, F10, and F12 were found to be optimum. They followed the non-ficikian mechanism of drug release.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
