Abstract
Aims The study was designed to evaluate Raf1, Aurora-A/STK15 and E-cadherin (E-CD) protein expression and their prognostic value in patients with pTa/pT1 tumours. Materials and methods A tissue microarray of 105 pTa, and 141 pT1 tumours was constructed and sections were immunostained with these three antibodies. Results There were significant associations between Raf1 overexpression and tumour grade ( p=0.03), between Aurora-A overexpression/alterations of E-CD and tumour grade and stage ( p<0.001 and p<0.001). In multiple Cox regression analysis, moderate/strong expression of E-CD seemed to be an independent factor in predicting slower tumour progression ( p=0.003) and Aurora-A overexpression ( p=0.022) displays an independent value in predicting tumour recurrences. Conclusion Evaluation of E-CD and Aurora-A expressions in tissue of patients with pTa/pT1 UC have been proven to be useful in predicting tumours behavior and Raf1 protein expression seemed to have no potential use in this regard.
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