Abstract
Gamma-aminobutyric acid (GABA) acts as an inhibitory transmitter in mature central nervous system. GABA/GABA-A receptors are also present in non-neural tissue, including ovary. We have shown a receptor specific effect of GABA-A on aromatase (CYP19) induction in cultured human granulosa cells (GC), which requires the presence of insulin. The 81-kDa actin-binding protein radixin (RDX) from ezrin/radixin/moesin family has been shown to directly link the alpha-5 subunit of GABA-A receptor to the cytoskeleton acts as membrane organizer and linker.
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