Abstract
BackgroundTo assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy.MethodsFifty-eight patients with T1-T2 squamous cell carcinoma of the glottis who were treated between 2001 and 2006 were analyzed retrospectively. Potential prognostic factors for LC were evaluated by univariate analysis.ResultsThe 5-year LC rate in all patients was 84.3%. The overall 5-year LC rates for patients with T1a, Tb, and T2 GC were 85.9%, 83%, and 85%, respectively. Of the 58 patients, eight developed recurrent disease at the primary site, and one had lymph node recurrences on the neck. In the final analysis, the total laryngectomy-free survival rate was 93% at five years, and the ultimate LC rates for T1a, Tb, and T2 were 100%, 90.9%, and 95.2%, respectively. In a univariate analysis of 55 patients, there was no statistical significance between the LC rate for RT alone and that for chemoradiation. Only two patients died of laryngeal carcinoma, and one died of intercurrent disease. Fifty-five patients were living disease-free at the end of the study period. The 5-year overall survival (OS) rate for all patients was 88.1%, and the 5-year OS rates for T1a, Tb, and T2 were 91.6%, 77.8%, and 89.9%, respectively.ConclusionsThe retrospective analysis showed a high rate of LC and larynx preservation in patients with T1-T2 GC by means of RT with or without chemotherapy. There was, however, no statistical difference in LC rates for the two types of therapy.
Highlights
To assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy
The advantages of RT in terms of preservation of the structure and function of the larynx have been documented extensively, and RT currently is the initial treatment of choice in most institutions, with surgery being reserved as a salvage option for local failure
Patient characteristics A retrospective review was performed of 58 patients who had undergone radical RT with or without chemotherapy to the larynx for Stage I-II GC (T1-T2, N0 according to the 2002 International Union Against Cancer classification system)
Summary
To assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy. Glottic carcinoma (GC), the most common laryngeal cancer, and is usually detected early because of the symptomatic occurrence of hoarse voice. The recommended strategies for early GC with the intent of larynx preservation are radiation therapy (RT), transoral laser therapy, and partial laryngectomy [1,2]. The advantages of RT in terms of preservation of the structure and function of the larynx have been documented extensively, and RT currently is the initial treatment of choice in most institutions, with surgery being reserved as a salvage option for local failure. For T1 GC, The purpose of this study was to review retrospectively our experience in the treatment of T1 and T2 GC through RT with or without chemotherapy from 2001 to 2006
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