Abstract
PurposeTo evaluate the efficacy of radiotherapy (RT) for early-stage nodal and extranodal marginal zone lymphoma (MZL).Materials and methodsPatients with stage I (n = 22) and stage II (n = 8) MZL, who were treated with RT were reviewed. The primary tumor localisation was in the orbita (n = 12), stomach (n = 8), head and neck other than the orbita (n = 8), breast (n = 1) and one case of marginal zone lymphoma of the skin (n = 1). The median radiotherapy dose was 40 Gy (5 to 45 Gy).ResultsThe median follow-up time was 103 months. The 5-year overall survival and event-free survival rates were 85 ± 7% and 71 ± 9%, respectively. There was no infield recurrence. Recurrence occurred outside of the radiation field in six patients. The relapses were treated with salvage RT and had excellent local control (100%) at five years after salvage RT.ConclusionsLocalized extranodal MZL have an excellent prognosis following moderate-dose RT. RT is also an effective salvage therapy in cases of localized recurrence. Further clinical studies should evaluate the optimal dose for MZL.
Highlights
Further clinical studies should evaluate the optimal dose for marginal zone lymphomas (MZL)
In 1984, Isaacson and Wright [1] described a group of lymphomas that derived from mucosa-associated lymphoid tissue (MALT)
We report the outcomes of a retrospective analysis of 30 patients with stage I-II MALTlymphoma treated with radiotherapy at our Institution
Summary
In 1984, Isaacson and Wright [1] described a group of lymphomas that derived from mucosa-associated lymphoid tissue (MALT). Today these lymphomas are well established as a distinct subtype of the marginal zone lymphomas (MZL) in the non-Hodgkin’s lymphoma classification. The most common localization is the gastrointestinal tract [2], especially the stomach, but MALT lymphomas arise from other epithelial structures as well. Those include regions in the head and neck area, e.g. the salivary glands, the thyroid gland or the orbita, breast and, though not typically mucosa-associated, in some cases the skin. Previous studies have shown excellent outcomes after radiotherapy in treatment of MALT lymphoma as an organ-preserving treatment modality [3] as has been shown for other indolent
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