Radiotherapy for Localized Gastric MALT Lymphoma: An Over 10.Year Single Institutional Retrospective Review

Abstract

BACKGROUND: MALT lymphoma is very slow progressive and low relapse rate, long-term follow-up is very important. However, there are limited reports of long-term observational study of MALT lymphoma. MATERIALS AND METHODS: A retrospective review was conducted on a total of 54 consecutive patients who were treated for localized gastric MALT lymphoma with radiotherapy from January 2007 to December 2019. Clinical staging was performed in reference and according to the Lugano Modification of Ann Arbor Staging System. The prescribed dose was 30 Gy with 15 or 20 fractionations. RESULTS: In the entire cohort, there were 30 males and 24 females with a median age of 64 years (range: 37–81 years). The median follow-up period was 38.1 months (range: 3.6–145 months), and there were no patients who died within the observation period, according to their medical records. All patients achieved a complete response, as proven by the biopsies conducted. Forty-eight patients (89%) achieved a complete response at the first biopsy after radiotherapy, 5 (9.2%) at the second time, and 1 (1.8%) at the fourth time. No patient had experienced locoregional recurrence; however, 3 patients did develop distant disease progression during the observation period. The 5- and 10-year progression-free survival rates were 93.4% (95% confidence interval (CI): 75.8%–98.3%) and 86.7% (95% CI: 61.7%–95.9%), respectively. No patient exhibited any Grade 3-5 late radiation-induced acute or late toxicity. CONCLUSION: This retrospective analysis clarified a clinical outcome of gastric MALT lymphoma treated by radiotherapy.