Radiotherapy for 308 patients with non-small cell lung cancer (NSCLC)

Abstract

To analyze the survival results retrospectively of the patients with NSCLC treated by radiotherapy alone and the clinical factors affecting the survival results. Three hundred and eight patients with NSCLC from January, 1985 to December, 1991 were included in this study (stage I, 11 cases; stage II, 68 cases; stage IIIA, 155 cases; stage IIIB, 74 cases). All patients were confirmed by pathology and cytology. They were treated by 10 MV-X ray or cobalt-60, conventionally fractionated, with weekly dose 7-11.5 Gy. In 47 patients of them treatment planning system was used at the beginning or in the middle of radiotherapy as to have the primary lesion and mediastinum in the full course of radiotherapy. In the rest of patients whose mediastinal dose was 40Gy by anterior and posterior fields, irradiation dose to the spinal cord was avoided and irradiation dose to the primary lesion got to the definitive treatment. The survival rate was analyzed by Kaplan-Meier and tested by Log-rank. The median survival was 10 months. The 1-, 3- and 5-year survival rates were 43%, 15% and 9% respectively. The earlier the clinical stage, the better the prognosis (P=0.0001). The survival rate of the patients with complete remission at the end of radiotherapy was better than that of the patients with residual tumor (P=0.0001). The survival of the patients with weekly dose larger than 10 Gy was better ( P=0.0461). There was no relationship among the survival rate and the total dose and mediastinal dose. The results show the survival rate of patient with NSCLC treated by radiotherapy alone was related to clinical stage, instant response and weekly dose, but not to the total dose and the mediastinal dose.