Radiotherapy cannot prolong overall survival of young prostate cancer patients with bone metastases.

Bo Peng,Cheng Yang,Jian He

doi:10.1186/s12967-016-0868-y

Abstract

BackgroundPatients with prostate cancer is commonly diagnosed with bone metastases. With the growing use of prostate-specific antigen testing, the frequency of prostate cancer has progressively increased in patients younger than 70 years. Radiotherapy is recognized for its effect on local control of bone metastases, but whether it could prolong overall survival is still controversial.MethodsA total of 113 prostate cancer patients (<70y) with bone metastases were retrospectively analyzed. The Kaplan–Meier method was used for survival analysis with log-rank test. Multivariate analysis was performed to find the prognostic factors with the COX regression model.ResultsThe 1-, 2-, 3-, 5-, 7- and 10-year survival rates were 97.14, 82.86, 62.61, 38.76, 25.83 and 13.84 % respectively in the radiotherapy group, and 92.75, 73.91, 54.66, 36.63, 26.03 and 17.85 % respectively in the non-radiotherapy group, which showed no significant difference. Multivariate COX regression showed the overall survival was associated with alkaline phosphatase when bone metastases occurred and the number of bone metastases.ConclusionWith the advances in life-prolonging treatment of metastatic prostate cancer, radiotherapy may not be the first choice for young bone metastatic prostate cancer patients in order to improve survival.

Highlights

Patients with prostate cancer is commonly diagnosed with bone metastases
Prostate cancer (PCa) is usually considered as a disease of advanced age, its frequency has progressively increased in patients younger than 70 years with the growing use of prostate-specific antigen (PSA) testing [2]
We reviewed 113 young PCa patients (

Summary

Introduction

Patients with prostate cancer is commonly diagnosed with bone metastases. Radiotherapy is recognized for its effect on local control of bone metastases, but whether it could prolong overall survival is still controversial. PCa is usually considered as a disease of advanced age, its frequency has progressively increased in patients younger than 70 years with the growing use of prostate-specific antigen (PSA) testing [2]. PCa prefers to metastasize to skeleton, patients with PCa in Radiotherapy (RT) is considered as an effective treatment for local control of bone metastasis, which could reduce the skeletal-related events (SREs) [4, 5]. The long-term effect of RT on bone metastases is still controversial In this retrospective study, we reviewed 113 young PCa patients (

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Results

Discussion

Conclusion