Radiotherapy and hyperthermia for NSCLC

Abstract

7289 Background: Up to now, NSCLC with tumor(T) larger in lungs treated with irradation(RT) has poorly loco-regional control limited by tolerance dose of normal tissues. The aim of this study is to observe the toxicity, tolerance and efficacy of RT combined with hyperthemia(HT) for NSCLC with T in diameter >= 5cm. Methods: Patients(pts) satisfied NSCLC, karnofski performance status>=70, the least diameter of T >=5cm or volume of T>=125cm3 prior to irradiation, tolerable to radical irradiated doses, expected survival > 3 months were received RT and HT.The temperature of HT in the center of Ts was monitored between 430 C and 43.50 C by computer with ZRL-II radio-frequency capacitive. The total T dosage was 60–66Gy in 30–33 fractions. Results: From September 2001 to April 2004, 30 Pts were registered for this study. The last day of follow up was September 2004. There were 23 males and 7 female with median age of 61 years (32–81), 22 cases squamous cancer, 8 cases adenocarcinoma. And 6 cases were stage I b, 1 case stage II b, 10 cases stage III a, 8caes stage III b, 5cases stage IV. The mean volumes of T were 275.45cm3(125–900). None of pts had changed significantly in blood pressure, pause and frequency of the breath. And lipid nodules, acute radiation-induced responses in Grade III and over had not also been observed. CR was observed in 23%, PR in 50%, NC in 27% and PD in 0%. Local relapse-free survival rate was 83% with median loco-regional duration of 19.17months. The median survival duration was 19.69 months. And the 1-year survival rate was 75%. Conclusions: The regimen of RT combined with HT could be used for NSCLC with T in diameter >=5cm which has better efficacy and loco-regional control without serious sides. No significant financial relationships to disclose.