Abstract
An improved production procedure and formulation method for the carbon-11 radiolabeled phytohormone, 3-indolyl-[l-11C]acetic acid ([11C]IAA), was developed by modifying selected original reaction parameters. This updated procedure both doubled the yield (from 25.9±6.7% (n=12) to 61.0±0.3% (n=10)) and increased the concentration (0.2–0.4GBq/0.15–0.3mL), enabling us to provide the radiotracer [11C]IAA suitable for in vivo phyto-PET-imaging studies. The specific activity was improved by more than a factor of three (26.7±5.6GBq/µmol to 82.5±36.1GBq/µmol). The total synthesis time for both production and formulation was 81.8±3.0min (n=10). In addition, a streamlined semi-remote controlled production system, containing five processing modules, was designed and built for routine [11C]IAA production. This integrated system facilitated routine high radiation level production of [11C]IAA while minimizing radiation exposure to the production chemists.
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