Abstract

Objective To investigate the radiosensitivity enhancement of Au nanoparticles to HepG2 cell.Methods 15 nm polyethylene-glycol-coated(PEG) Au nanoparticles were synthesized,and then blood stability were tested by using the UV-vis optical absorption.Meanwhile,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods were used to investigate the cell viability after 24 and 48 hours treatments,and cloning formation were used to investigate the radiosensitivity enhancement.Results It was found that PEG-coated Au nanoparticles presented a high blood stability,and surface plasmon response has not shown significant changes after 24 hours.Cell viability was decreased after 24 hours treatment,but it was recovered to 90％ after 48 hours.Cloning formation showed Au nanoparticles presented a significant radiosensitivity enhancement.Conclusion 15 nm PEG-coated Au nanoparticles presented a good blood stability,low cytotoxicity and high radiosensitivity enhancement. Key words: Polyethylene glycols; Gold nanoparticles; Radiation sensitizing

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.