Abstract
The injection of spleen cells from donors of parental strain into F 1 hybrid mice results in paravascular infiltration (PVI) in the portal tracts of the recipients' livers. The infiltrates can be enumerated. Whole-body irradiation (802 r) of the recipients before the injection of parental spleen cells does not reduce the number of PVI formed. Irradiation (1500 r) of the donors eradicates the capacity of their spleen cells to produce PVI. In vivo radiation inactivation experiments indicate that the LD 37 for donor PVI-producing cells is approximately 47 r and the D 0 is 102 r. These data support the contention that the formation of PVI is a function of donor cells and depends upon cell division.
Published Version
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