Abstract
Prostate cancer occurs frequently in men and can often lead to death. Many cancers, including prostate cancer, can be initiated by oxidative insult caused by free radicals and reactive oxygen species. The superoxide dismutase family removes the oxygen-derived reactive oxygen species, and increased superoxide dismutase activity can often be protective against prostate cancer. Prostate cancer can be treated in a variety of ways, including surgery, androgen deprivation therapy, radiation therapy, and chemotherapy. The clinical trajectory of prostate cancer varies from patient to patient, but more aggressive tumors often tend to be radioresistant. This is often due to the free-radical and reactive-oxygen-species-neutralizing effects of the superoxide dismutase family. Superoxide dismutase 2, which is especially important in this regard, can be induced by the NF-κB pathway, which is an important mechanism in radioresistance. This information has enabled the development of interventions that manipulate the NF-κB mechanism to treat prostate cancer.
Highlights
IntroductionTreatments for prostate cancer include surgery, radiation, and androgen deprivation, among other therapies
We review first the basics of prostate cancer and its treatment; the role of the NF-κB pathway in superoxide dismutase (SOD) induction and radioresistance; the role
This study found that both prostatic intraepithelial neoplasia (PIN) and prostate cancer had lower SOD1, SOD2, and catalase than benign tissue, results that support data reported earlier [51,52]
Summary
Treatments for prostate cancer include surgery, radiation, and androgen deprivation, among other therapies. Often these therapies are used in combination with each other. The superoxide dismutase (SOD) family consists of SOD1, SOD2, and SOD3 proteins that neutralize the first oxygen-derived ROS and provide protection against the development of cancers, including prostate cancer. A side effect of neutralizing the ROS is that the cancer cells survive radiotherapy and have prometastasic characteristics. In this minireview, we review first the basics of prostate cancer and its treatment; the role of the NF-κB pathway in SOD induction and radioresistance; the role. Antioxidants 2021, 10, 1925 of the SOD family in prostate tissue and prostate cancer; and focus on the present translational interventions that utilize the NF-κB pathway and knowledge about SOD
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
