Radioprotective Effects in Mice by a Single Dose of Subcutaneous Administration of Cobaltous Chloride Post .GAMMA.-Rays Irradiation with a Sublethal Dose.

Abstract

Radioprotective effects were investigated in mice which received subcutaneously a single dose of each inorganic metal: Co, Cu, Rb, Sr, Mo and W 24h post irradiation of 60Co γ-rays with a sublethal dose.The effects were observed in mice injected with Co at an optimum dosage of 20 mg/kg· body weight. Then to elucidate mechanisms of the effects, mice were injected with Co containing the radioactive tracer (60Co) following the radiation exposure, measured elimination of the radioactivity for 7 days, then sacrificed and divided to some tissues and organs. The radioactivity in whole body during this period resulted in a markedly higher retention than that for mice injected with [60Co] alone, as well as liver in the organs. These higher retentions appeared to be related to the radioprotective effects.