Abstract
Background:Thymoquinone, has anti-inflammatory, anti-oxidant, and cardio protection properties. This study aimed to evaluate the radioprotective effect of thymoquinone in whole body X-irradiated rats. Methods:This study conducted on 40 male adult Wistar albino rats randomized into the following groups: Group I: Control rats did not receive thymoquinone or ionizing radiation. Group II: Whole-body irradiated rats with 6 Gy of X-ray. Group III: Rats orally intubated with thymoquinone (10 mg/kg/day) for 7 days then subjected to whole-body irradiation with 6 Gy then supplemented with thymoquinone for another 7 days. Group IV: Rats orally intubated with thymoquinone (20 mg/kg/day) for 7 days then subjected to whole-body irradiation with 6 Gy then supplemented with thymoquinone (20 mg/kg/day) for another 7 days. LDH, CK-MB, ALT, AST, MDA, TAC, Catalase activity, GPX, GSR and GSH were measured. Results:Lipid peroxidation biomarker in the blood of X-irradiated rats significantly increased and accompanied by decrease in the levels of GSH, GSR, GPX, catalase as well as TAC. Moreover, exposure to IR significantly increases cardiac and liver enzymes. However, administration of TQ to X-irradiated rats with either 10 mg/kg or 20 mg/kg have the same reform effects and significantly protects rats against adverse effects of IR. Conclusion:Exposure to X-ray leads to significant changes in cellular biochemical and morphological conditions. Administration of TQ before radiation treatment significantly decreases the adverse effects of IR. TQ can improve cardiac function, decrease myocardial enzyme levels and inhibit oxidative stress.
Highlights
Ionizing radiation (IR) emission is a process in which an unstable nucleus emitted the excess energy to achieve stability
Group III: 10 Rats orally intubated with thymoquinone (10 mg/kg body weight/day) for 7 days subjected to whole-body irradiation with 6 Gy of x-ray the rats were supplemented with thymoquinone (10 mg/kg body weight/day) for another 7 days
Group IV: 10 Rats orally intubated with thymoquinone (20 mg/kg body weight/day) for 7 days subjected to whole-body irradiation with 6 Gy of x-ray the rats were supplemented with thymoquinone (20 mg/kg body weight/day) for another 7 days
Summary
Ionizing radiation (IR) emission is a process in which an unstable nucleus emitted the excess energy to achieve stability. Long-term IR exposure causes adverse effects in the body, such as cancer, skin redness, lowered immunity, and serious damage to organs and tissues due to formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) (Hosoda et al, 2021; Wang et al, 2020). Group III: Rats orally intubated with thymoquinone (10 mg/kg/day) for 7 days subjected to whole-body irradiation with 6 Gy supplemented with thymoquinone for another 7 days. Group IV: Rats orally intubated with thymoquinone (20 mg/kg/day) for 7 days subjected to whole-body irradiation with 6 Gy supplemented with thymoquinone (20 mg/kg/day) for another 7 days. Results: Lipid peroxidation biomarker in the blood of X-irradiated rats significantly increased and accompanied by decrease in the levels of GSH, GSR, GPX, catalase as well as TAC. Administration of TQ before radiation treatment significantly decreases the adverse effects of IR. TQ can improve cardiac function, decrease myocardial enzyme levels and inhibit oxidative stress
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