Abstract
Ionizing radiation has cytotoxic and genotoxic effects caused mainly by the oxidative damage induced by free radical release. The need for radioprotectives is increasing to protect normal tissues during radiotherapy. In the present study, we investigated the radioprotective effect of Date syrup in rats subjected to whole body radiation at 6 Gy through biochemical, molecular and histopathological analysis. Significant elevations were recorded in the activities of serum ALT, AST, ALP and LDH and in the levels of all lipid profiles parameters, while the level of HDL-C was reduced. The concentration of liver MDA was elevated with depletion of hepatic glutathione (GSH) and catalase. DNA damage was evidenced by increased DNA strand breakage and DNA-protein crosslinks. Significant elevations were observed in the expression of liver TNF-α and serum activity of matrix metalloproteinase (MMP-9). Pretreatment of rats with Date syrup ameliorated the tissue damage induced by radiation as evidenced by the improvement of liver function, antioxidant status and reduction of DNA damage. Besides, liver TNF-α expression and serum MMP-9 activity were reduced. In conclusion, Date syrup could alleviate the toxic effects of ionizing radiation and thus is useful as a radioprotective in radiotherapy regimen.
Highlights
Ionizing radiation results in an array of biological consequences, including inflammation, carcinogenesis, and death
0.05) in rats of Irradiated group that exposed to whole body irradiation in comparison with control
Our findings revealed that irradiation of rats induced significant increases in serum cholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein-cholesterol (VLDL-C) levels while HDL-C was reduced
Summary
Ionizing radiation results in an array of biological consequences, including inflammation, carcinogenesis, and death. Radiotherapy is beneficial in controlling tumors in human and animals, it induces damages to the bone marrow, liver and other tissues. These limit the therapeutic dose of radiation that is essential to control tumors[1]. Because free radicals are the main cause of irradiation-induced cellular damage, antioxidants and free radical scavengers are expected to act as radioprotectors. This causes biologists and radiation oncologists seek continuously for radioprotectors
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