Abstract
EMT6 tumors were transplanted intramuscularly in the right hind leg of female BALB/c mice and irradiated when they reached a diameter of 6-7 mm. Each mouse received an intraperitoneal injection of WR-2721, misonidazole, or both prior to irradiation, and the dose needed to control half of the tumors at 30 days (TCD50/30) was recorded. WR-2721 offered slight tumor protection, with a dose-modifying factor (DMF) of 1.04-1.15 for radioprotector doses of 150-500 mg/kg. Pretreatment with misonidazole at doses of 300-900 mg/kg yielded tumor sensitization with a DMF of 0.71-0.92. Pretreatment with both WR-2721 and misonidazole gave overall tumor sensitization with a DMF of 0.78-0.97. Possible combinations of sensitizers and protectors, while providing overall tumor sensitization, do not seem to improve the therapeutic ratio over what could be obtained from a sensitizer or protector alone.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
