Abstract
INTRODUCTIONPREVIOUS work in our laboratory indicated that bone mineralization of S35O4 in chicks fed a natural feedstuffs diet supplemented with vitamin B12 was decreased as compared to that in chicks fed the same non-supplemented diet or a simplified diet with vitamin B12 (Martin and Patrick, 1960). Inorganic sulfate is incorporated into to chondroitin sulfate moiety of skeletal tissue (Bostrom and Mansson, 1952). Jackson and Ball (1953) and Layton (1950) have presented data indicating that chondroitin sulfate, a major component of the ground substance of connective tissue, plays an important role in the metabolism of connective tissue possibly associated with calcification. Since vitamin B12 has been shown by many workers to increase the growth rate of animals, it is reasonable to assume that increased sulfate uptake by connective tissue may be influenced by this vitamin.This study was designed in an effort to ascertain the factor or factors in the …
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