Abstract

Radionuclide detection of apoptosis with of (99m)Tc-Hynic-rh-Annexin V scintigraphy is an effective tool for in vivo visualisation and monitoring of apoptosis in various malignant tumour. Early therapy-induced increase of the tumour tracer uptake correlates with favourable outcome, whereas stable or decreased uptake correlates with stable disease or tumour progression. Therefore sequential (99m)Tc-Hynic-rh-Annexin V scintigraphy could be used to predict therapy outcome on a patient-to-patient basis within 48 hours after the start of treatment. However, moderate tumour-to-background ratio and therapy-induced changes in normal tissues could confound image analysis. To assure accurate interpretation of Annexin V scans, the awareness of the biophysiological and biochemical properties contributing to the tracer distribution is essential. In with manuscript we discuss the patterns of Annexin V tumour uptake and illustrate the most frequent pitfalls associated with Annexin V imaging in correlation with CT and MRI imaging.

Highlights

  • Radionuclide detection of apoptosis with of 99mTc-Hynic-rh-Annexin V scintigraphy is an effective tool for in vivo visualisation and monitoring of apoptosis in various malignant tumours[1,2]

  • In our previous publications we reported the pattern of the tracer uptake in low grade lymphomas, non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma

  • In vivo visualisation of acute platelet-rich thrombi by means of Annexin V scintigraphy is widely discussed in the literature[26,27,28].Tracer affinity to PS exposed on the surface of activated platelets explains tracer accumulation on the compromised vessels

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Summary

METHODOLOGY

Radionuclide Imaging of Apoptosis in Malignancies: Promise and Pitfalls of 99mTc-Hynic-rh-Annexin V Imaging. Verheij[2], B.L. van Eck[3], C.A. Hoefnagel[1] and R.A. Valdes Olmos[1]

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