Radiomics-based differentiation of lung disease models generated by polluted air based on X-ray computed tomography data

Krisztián Szigeti,Tibor Szabó,Dániel S Veres,Ilona Czibak,Kinga Karlinger,Domokos Máthé,Ferenc Budán,Ildikó Horváth,Ralf Bergmann,Márta Pócsik,Csaba Korom,Zoltán Gyöngyi

doi:10.1186/s12880-016-0118-z

Abstract

BackgroundLung diseases (resulting from air pollution) require a widely accessible method for risk estimation and early diagnosis to ensure proper and responsive treatment. Radiomics-based fractal dimension analysis of X-ray computed tomography attenuation patterns in chest voxels of mice exposed to different air polluting agents was performed to model early stages of disease and establish differential diagnosis.MethodsTo model different types of air pollution, BALBc/ByJ mouse groups were exposed to cigarette smoke combined with ozone, sulphur dioxide gas and a control group was established. Two weeks after exposure, the frequency distributions of image voxel attenuation data were evaluated. Specific cut-off ranges were defined to group voxels by attenuation. Cut-off ranges were binarized and their spatial pattern was associated with calculated fractal dimension, then abstracted by the fractal dimension -- cut-off range mathematical function. Nonparametric Kruskal-Wallis (KW) and Mann–Whitney post hoc (MWph) tests were used.ResultsEach cut-off range versus fractal dimension function plot was found to contain two distinctive Gaussian curves. The ratios of the Gaussian curve parameters are considerably significant and are statistically distinguishable within the three exposure groups.ConclusionsA new radiomics evaluation method was established based on analysis of the fractal dimension of chest X-ray computed tomography data segments. The specific attenuation patterns calculated utilizing our method may diagnose and monitor certain lung diseases, such as chronic obstructive pulmonary disease (COPD), asthma, tuberculosis or lung carcinomas.Electronic supplementary materialThe online version of this article (doi:10.1186/s12880-016-0118-z) contains supplementary material, which is available to authorized users.

Highlights

Lung diseases require a widely accessible method for risk estimation and early diagnosis to ensure proper and responsive treatment
The fractal dimension - cut-off range functions were evaluated by fitting them with Gaussian curves “A” and “B” (Fig. 4)
The mean of height of “B” curve of the SDO group increased significantly when compared to the CON group (KW p = 0.002, Mann–Whitney post hoc (MWph) p = 0.036) and to the SAO group (KW p = 0.002, MWph p = 0.024), but not significantly when the CON group was compared to the SAO group (Fig. 5b top)