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Abstract
A METHOD for the microdetermination of acetylcholinesterase activity has been developed in which the formation of acetic acid labelled with carbon-14, liberated enzymically from the labelled substrate, is measured by a simple counting technique. The method has the advantage that it can be applied to very small samples of tissue at relatively constant pH. It has been applied successfully to samples of the order of 1 µl. of whole blood, blood plasma, or insect tissue deposited on cavity-type microscope slides. Since dilution of the sample is unnecessary or readily limited without affecting sensitivity, the technique provides a more reliable indicator of reversible cholinesterase inhibition by compounds such as carbamates than the conventional Michel method1, for example.
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