Abstract
Exciting events in diagnostic radiology occurring over the past year include the development of a model of atherosclerosis at the University of Washington (Seattle) Medical Center by Goldman et al<sup>1</sup>using Yucatan microswine. The lesions are established by placing the animal on a high-fat diet and using intra-arterial balloons to denude the vascular endothelium. Histopathologic lesions identical to those observed in human atherosclerotic vascular disease may not develop for 5 or more months. The lesions reveal a fibrous cap with intimal hyperplasia, foam cells, necrosis, and calcification. The advantage of producing such lesions in this model is that arteries similar in size to the superficial femoral artery are accessible. This model was developed for the purpose of evaluating angioplasty devices, including various balloons, instruments for atherectomies, and lasers. Effectiveness of therapy, complications, and the occurrence of restenosis may be studied using this model. In addition, it can be used
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
