Abstract
Familial combined hyperlipidemia is a genetic dyslipidemia (Mendelian Inheritance in Man 144250) associated with hepatic lipoprotein overproduction, insulin resistance, and increased plasma concentrations of free fatty acids ( 1 van der Kallen C Voors-Pette C Bouwman F et al. Evidence of insulin resistant lipid metabolism in adipose tissue in familial combined hyperlipidemia, but not type 2 diabetes mellitus. Atherosclerosis. 2002; 164: 337-346 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar ). Similar alterations in metabolism occur in nonalcoholic fatty liver disease ( 2 Angulo P Nonalcoholic fatty liver disease. N Engl J Med. 2002; 346: 1221-1231 Crossref PubMed Scopus (4084) Google Scholar ) (which includes both nonalcoholic fatty liver and nonalcoholic steatohepatitis). The definitive diagnosis of the different stages of nonalcoholic fatty liver disease requires examination of a hepatic biopsy specimen, but ultrasonography is a highly sensitive (89%) and specific (93%) method to assess steatosis ( 3 Joseph A.E Saverymuttu S.H al-Sam S et al. Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease. Clin Radiol. 1991; 43: 26-31 Abstract Full Text PDF PubMed Scopus (437) Google Scholar ). We assessed the prevalence of nonalcoholic fatty liver disease, as diagnosed with ultrasonography, in patients with familial combined hyperlipidemia.
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