Abstract
Radiological assessment of bioengineered bone in a muscle flap for reconstruction of a critical-size mandibular defect
Highlights
Loss of bone due to trauma, infection or resection of pathological lesions results in large, osseous, segmental defects of the facial skeleton which are difficult to reconstruct
This study evaluated the reconstruction of critical size mandibular defects in rabbits using a pedicled masseter muscle flap which was injected with calcium sulphate/hydroxyapatite cement (CERAMENTTM|SPINE SUPPORT), bone morphgenic proteins (BMP)-7 and rabbit mesenchymal stromal cells
Plain radiographic assessment ‘‘oblique extra-oral film’’ At day 0 the injected cement appeared as bright radio-opaque patches covering the surgical defect
Summary
Loss of bone due to trauma, infection or resection of pathological lesions results in large, osseous, segmental defects of the facial skeleton which are difficult to reconstruct. Many strategies have been proposed for the management of mandibular surgical defects following bone loss, vascularized autogenous bone grafts are considered the most reliable method for reconstruction. This type of graft is not suitable if the patient has been subjected to radiotherapy or is suffering from peripheral vascular disease which compromises the blood supply to the surgical site. The applications of vascular endothelial growth factors (VEGF), angiogenic proteins and hypoxia induced factor1a to improve vascularity at the surgical site have been reported [8,9,10]
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