Abstract
Graphene oxide (GO) was synthesized by modified Hummers method and was characterized using HR-TEM, FTIR, XRD and zeta potential. The antibacterial activity of GO towards gram-positive bacteria such as Staphylococcus aureus was investigated in vitro. Different parameters were used to study the GO labeling by 99mTc. Under optimum conditions, the labeling yield of 99mTc-GO complex is 91%. Biodistribution studies in Swiss Albino rats were carried out in experimentally induced infection in the left lateral thigh using Staphylococcus aureus. The biodistribution study revealed that the optimum accumulation of 99mTc-GO at the infection sites is 4.21 ± 0.32 at 60 min.
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