Abstract
A procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing agent in acetone at 40°C for 20 min, a maximum radiochemical yield of 125I-Ceph (95%) was obtained. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal and inflamed (septic and aseptic) mice indicates the suitability of radioiodinated cephalexin for imaging of inflammation
Highlights
Cephalexin is a first-generation cephalosporin antibiotic, introduced in 1967 by Eli Lilly and Company [1]
Cephalexin and other first-generation cephalosporins are known to have a modest cross-allergy in patients with penicillin hypersensitivity
The results indicate, at low amounts of cephalexin
Summary
Cephalexin is a first-generation cephalosporin antibiotic, introduced in 1967 by Eli Lilly and Company [1]. In addition to being a rational first-line treatment for cellulitis, it is a useful alternative to penicillins in patients with penicillin hypersensitivity. Caution should always be taken when prescribing cephalosporins to those with strong history of true penicillin hypersensitivity [3]. Cephalexin and other first-generation cephalosporins are known to have a modest cross-allergy in patients with penicillin hypersensitivity. It works by interfering with the bacteria’s cell wall formation. This weakens the cell wall, causing its rupture, and killing of the bacteria
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