Abstract

High-performance liquid chromatography and radioimmunoassay were used to identify the prostaglandins synthesized by mouse embryo palate mesenchyme cells. Serum stimulated the release of several different metabolites of arachidonic acid including 6-ketoprostaglandin F 1α (the stable product of prostacyclin, prostaglandin I 2), prostaglandin E 2 and prostaglandin F 2α. Compared to control cells, the serum-stimulated cells produce elevated levels of prostaglandin E 2 (36-fold), 6-ketoprostaglandin F 1α (15-fold) and prostaglandin F 2α (7-fold). The acetylenic analogue of arachidonic acid, 5,8,11,14-eicosatetraynoic acid prevented this accelerated synthesis.

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