Abstract
One hundred and thirty determinations of plasma radioimmunoassayable luteinizing hormone (LH) levels were carried out in 35 patients, ages 14 to 37, presenting with primary amenorrhea. Of these subjects, 11 (Group 1) had hypogonadotropic hypogonadism; 16 (Group 2) had gonadal dysgenesis; 8 (Group 3) had uterovaginal atresia. Mean LH levels were, respectively, 9.1 ± 5.3 mLU. per milliliter (Second International Reference Preparation of human menopausal gonadotropin) in Group 1, 61.5 ± 19.5 mI.U. per milliliter in Group 2, and 11.9 ± 9 mI.U. per milliliter in Group 3 (mean ± 1 S.D.). The difference between the plasma LH levels found in Group 2 and those found in Groups 1 and 3 was statistically significant (p < 0.001). No overlap was found between plasma LH levels of patients with hypogonadotropic hypogonadism and those of patients with gonadal dysgenesis, indicating the reliability of differentiation by LH assay. In the gonadal dysgenesis group plasma LH showed wide day-to-day fluctuations. In patients with uterovaginal atresia, high values were only occasionally recorded, possibly representing ovulatory peaks.
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