Radiographic Lung Abnormalities in First-Degree Relatives of Patients With Different Subtypes of Pulmonary Fibrosis

Abstract

Early interstitial lung disease (ILD) has been detected in 14% to 22% of screened relatives of patients with familial pulmonary fibrosis.1,2 Relatives of patients with sporadic IPF have been found with a higher prevalence of interstitial lung abnormalities (ILA) and preclinical ILD than the general population.3 Despite advances made in screening, many previous cohorts have excluded individuals with nonidiopathic pulmonary fibrosis (IPF) ILD. Therefore, we sought to determine the prevalence of subclinical ILD in family members of patients with fibrotic ILD, regardless of subtype.