Abstract
Objective: To radiographically evaluate the alveolar bone level after periodontal full mouth disinfection (FMD) treatment in women during chemotherapy (CHE) and hormone therapy with Tamoxifen (TAM). Material and Methods: This is an uncontrolled clinical trial with a convenience sample of women in antineoplastic treatment (CHE and TAM) and non-surgical periodontal FMD treatment. The Radiographic examination consisted of four bitewing radiographs and six periapical radiographs of the upper and lower anterior teeth, acquired according to the parallelling standard technique at three times: before (T0), 3 (T3) and 6 (T6) months after periodontal treatment. The alveolar crest level in the interproximal area of each tooth was measured by two calibrated observer using magnifying glass and digital caliper. Statistical analysis was performed for evaluation of the three times in each experimental group using the Friedman test (p 0.05). Conclusion: Patients undergoing chemotherapy and hormone therapy with Tamoxifen showed better alveolar bone levels after six months of periodontal FMD treatment. The current antineoplasic therapy did not influence the results obtained with periodontal treatment.
Highlights
Inflammation is a common feature of many chronic diseases such as periodontal disease and cancer [1,2]
The Radiographic examination consisted of four bitewing radiographs and six periapical radiographs of the upper and lower anterior teeth, acquired according to the parallelling standard technique at three times: before (T0), 3 (T3) and 6 (T6) months after periodontal treatment
The alveolar bone level showed statistically significant reduction after 6 months of full mouth disinfection (FMD) therapy (p 0.05)
Summary
Inflammation is a common feature of many chronic diseases such as periodontal disease and cancer [1,2]. Since most tumors have positive estrogen-like receptors, hormone therapy is considered effective and less toxic in the clinical management of patients with breast cancer [6]. This type of treatment basically works with two types of drugs that have different mechanisms of action and side effects: Tamoxifen and Aromatase Inhibitors. While Tamoxifen has a tendency to maintain bone mass in postmenopausal women [7], aromatase inhibitors work by suppressing serum estrogen levels [6] and are associated with negative indicators of periodontal disease [8]. Chemotherapy is associated with premature ovarian failure, which causes a decrease in bone mineral density [9,10] and can affect the periodontal condition of patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
