Abstract
This retrospective, single-center study evaluated radiofrequency (RF) ablation for pulmonary metastases of sarcoma. Forty-six patients with sarcoma (144 pulmonary metastases) underwent 88 RF ablation sessions. Data regarding local tumor progression, efficacy, procedural adverse events (AEs; National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0), overall survival (OS), and OS-associated prognostic factors were retrospectively evaluated using univariate analyses. Local progression occurred in 22 of 144 tumors (15.3%). Primary and secondary efficacy rates were 83.5 and 90.0% at 1year and 76.3 and 81.4% at 2years, respectively. Seventy-three grade 1 AEs, 33 grade 2 AEs, and no grade≥3 AEs were observed. Twenty-eight patients (60.9%) remained alive and 18 died, yielding 1-, 2-, and 3-year OS rates of 80.6, 70.1, and 47.1% (median survival time, 31.7months). Univariate analysis revealed extrapulmonary metastasis (P=0.005), noncurative RF ablation (P=0.009), and a post-RF ablation disease-free interval of ≤12months (P=0.015) as significant negative prognostic factors. RF ablation is safe, offers good local control, and may be a viable treatment option for pulmonary metastasis of sarcoma.
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