Abstract

In the past four decades, the incidence of esophageal adenocarcinoma has increased by 500%, paralleled by a similar increase in the rate of death associated with this often fatal disease.1,2 This type of esophageal cancer develops from a precursor lesion known as Barrett's esophagus, a condition in which the normal squamous esophageal lining is replaced by columnar epithelium containing intestinal metaplasia. In a small subgroup of patients, Barrett's esophagus may undergo a transition from low-grade or high-grade dysplasia to esophageal adenocarcinoma.3 The current standard of care is to enroll patients with Barrett's esophagus in endoscopic surveillance programs and to . . .

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