Radiofrequency ablation for liver metastases in patients with gastric cancer as an alternative to hepatic resection

Jin Won Lee,Han Mo Yoo,Cho Hyun Park,Young Joon Lee,Kyo Young Song,Bandar Ali,Moon Hyung Choi

doi:10.1186/s12885-017-3156-1

Jin Won Lee, Han Mo Yoo + Show 5 more

Open Access

https://doi.org/10.1186/s12885-017-3156-1

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Abstract

BackgroundThe purpose of this retrospective study was to determine whether RFA could provide an alternative treatment modality for selected patients who are not candidates for hepatic resection.MethodsA total of 18 consecutive patients with liver metastases alone from gastric cancer treated with radiofrequency ablation (RFA, n = 11) or hepatic resection (HR, n = 7) at Seoul St. Mary’s Hospital, Korea, between January 2000 and September 2014, were enrolled.ResultsThe median OS and DFS in the RFA group were 40.5 ± 22.3 and 10.3 ± 1.07 months, respectively. There was no significant difference between the RFA and HR groups in terms of baseline characteristics except for performance status. Mean survival and DFS times of all patients were 60.1 ± 9.4 and 40.9 ± 10.2 months, respectively. Mean OS times in the HR and RFA groups were 67.5 ± 15.4 and 51.1 ± 9.8 months (P = 0.671), respectively, and the mean DFS time in the HR group (74.1 ± 14.2 months) was longer than that in the RFA group (26.9 ± 9.2 months), but the difference was not significant (P = 0.076).ConclusionsIn patients who are not candidates for surgical treatment, RFA may be an alternative to HR.

Highlights

The purpose of this retrospective study was to determine whether radiofrequency ablation (RFA) could provide an alternative treatment modality for selected patients who are not candidates for hepatic resection
There was no significant difference between the groups in terms of baseline characteristics or tumor-related factors except for systemic chemotherapy after Hepatic resection (HR) or RFA
Systemic chemotherapy after procedures was administered in 87.5% of patients who underwent HR and 36.4% of patients who underwent RFA

Summary

Introduction

The purpose of this retrospective study was to determine whether RFA could provide an alternative treatment modality for selected patients who are not candidates for hepatic resection. Many patients with gastric liver metastases have accompanying peritoneal dissemination, extensive lymph node metastases, direct invasion of adjacent organs, and metastatic tumors involving multiple segments, which preclude HR at the time of presentation. Various treatments such as systemic chemotherapy, Lee et al BMC Cancer (2017) 17:185 hepatic arterial infusion (HAI) chemotherapy, radiotherapy, and radiofrequency ablation (RFA) have been proposed to improve outcomes [9,10,11]

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