Abstract
However, only one-third of patients are surgical candidates due to their advanced stage at presentation or medical comorbidities. 4 In these patients, the treatment options rely on radiotherapy (RT) with or without chemotherapy. In a meta-analysis determining the effectiveness of radical RT for stage I/II medically inoperable NSCLC patients, overall five-year survival ranged 0‐42%, with complete response rates of 33‐61% and local failure rates ranging 6‐70%. 5 The role of chemotherapy in NSCLC has primarily been for patients with more advanced disease alone or in conjunction with radiotherapy. Recently, two large studies evaluating the addition of chemotherapy to surgery for stage I and II NSCLC showed a 12‐15% improvement in survival in the chemotherapy group compared with surgery alone. 6,7 Clearly, even in early
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