Radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma

Abstract

Objective To investigate the treatment of interstitial implantation of ^125Ⅰ seeds feasibility, security, and short-term efficacy of combined and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma. Methods From December 2001 to December 2005, 26 cases of recurrent colorectal adenocarcinoma underwent Mile＇s procedure were treated with the radiochemotherapy. We implanted alternately ^125Ⅰ seeds and 5-FU slow-released seeds following the treatment planning system. The matched peripheral dose （MPD） of ^125Ⅰ seed implantation was 90-130 Gy. Twelve granules of ^125^Ⅰ seeds and 600 mg of 5-FU were administered in every patient on average. Results No operation-related complication was occurred during the implantations for all the cases. No displacement of ^125Ⅰ seed was found by pelvic X-ray examination. Lenitive rate of the pain was 88.9% （16/18） .The relief has lasted for 5-10 days on average. CT scanning showed that the size of tumor reduced in various degree at 3-6 months after the implantation. The complete recovery rate was 7.7% （2/26）, the partial recover）＇ rate was 73.1% （ 19/26）. The PD was 15.4% （4/26）. The median survival time was 29 months estimated by following these cases for 6-42 months. One case died of bone and lung metastases at 6 months after the implantation. Conclusion Combined radiochemotherapy with interstitial implantation of ^125Ⅰ seeds and 5-FU slow-released seeds was a safe and effective microinvasive treatment for recurrent colorectal carcinoma. Key words: Colorectal carcinoma; ^125Ⅰ seeds; 5-FU slow-release seeds; Brachytherapy