Abstract
A novel method was developed for the assay of nortriptyline in plasma. After nortriptyline was extracted, it was acetylated with 3H-acetic anhydride; the quantity of 3H-acetylnortriptyline in the extract was determined by radiochemical GLC. The method is capable of assaying 5 ng of nortriptyline/ml of plasma. The instrumentation was assembled from commercially available components.
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