Abstract
Radioautographic studies with 3H-inulin, 35SO4- and 38Cl- have been done on rat and guinea pig thyroids. Either 2 or 24 hr after the injection of the radioisotope, 3Hinulin distributed only in the interstitial (stromal) space of the thyroid gland. Since inulin does not penetrate the thyroid follicle, it is a satisfactory substance to measure the extrafollicular space of the thyroid gland. Both 36SO4 and 38Cl- distributed differently than did 3H-inulin. In addition to the stromal space, sulfate and chloride also enter the lumen of the thyroid follicle. However, the volume of distribution of 36SO4- is different from that of 35Cl-. The evidence indicates that most of the 35SO4- in the thyroid follicle is present in the lumen. In TSH-pretreated animals, more 36SO4- and 36C1- moved into the thyroid follicles, and the potential difference between the stroma and lumen, calculated from the 30Cl- ratios, decreased.(Endocrinology 77: 818, 1965)
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