Abstract
Radiocomplextion of zoledronic acid (ZL), a potent bisphosphonate with Lutetium-177, was investigated. The 177Lu-ZL complex was assessed for its radiochemical purity, in vitro stability and bone uptake by scintigrpahic images. A stable 177Lu-ZL complex was observed with > 99.0±0.5% radiochemical yield and remained stable for more than 7 hours in vitro by mixing 12mg ZL, 5mCi activity of 177LuCl3 produced by thermal neutron irradiation (~1.2× 1014 n.cm-2s-1) of enriched Lu2O3 samples in Pakistan Research Reactor-1 (PARR-I), at pH 7-8. Radiochemical purity was determined by PC, ITLC and HPLC. The biodistribution of 177Lu-ZL in rabbit was studied by SPECT imaging. The 177Lu-ZL showed significant uptake in the bone, which was scintigrpahically confirmed after whole body scanning. Due to better physical properties of 177Lu as compared to Sm-153 and acceptable biodistribution of the compound, 177Lu-ZL seemed to be an interesting new candidate for bone pain palliation therapy of skeletal metastases.
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