Radio-frequency drying of tablet granulations*

Abstract

This project was undertaken to survey the possibilities of utilizing radio-frequency drying of tablet granulations for future work of a more extensive nature. Two possible theories concerning the actual mechanism of nonconductor materials in a radio-frequency field are reviewed explaining how the nonconductor material becomes heated from within rather than by application of heat to its perimeters and the subsequent transfer of the heat to the center. A number of important electrical considerations regarding the size and materials of construction of the electrodes and their positions relative to one another are discussed. A table of thirty-one chemicals, with the percentage of added water removed, the period of drying time, and the peak radio-frequency voltage used, is given.